Stem Cells for Personalized Pain Therapy Testing

Chronic Pain News, Regenerative medicine
Using patient-derived stem cells, researchers create laboratory neuron models that reflect a patient’s response to a pain drug. Pain can be tough to take, and it’s also difficult to study: rodent models for pain do not necessarily translate to human pain conditions and expression of disease-causing mutations in cell lines may not precisely mimic the physiology of human pain disorders. Now, researchers have developed a new way to test pain—and, potentially, other sensory-targeting medications. Edward Stevens and James Bilsland of the Pfizer’s U.K.-based neuroscience and pain research units and their colleagues have shown that induced pluripotent stem cells (iPSCs) derived from blood samples of patients with a pain disorder can be used to create sensory neurons that recapitulate the disease phenotype. Testing a novel pain inhibitor on the patient-derived, iPSC-based…
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Full-length Protein Involved in Chronic Pain

Chronic Pain Conditions, Chronic Pain News
Researchers Map Full-length Protein Involved in Chronic Pain, with Hopes for Future Therapies Case Western Reserve University School of Medicine researchers have discovered the full-length structure of a protein named Transient Receptor Potential Vanilloid subtype 2 (TRPV2), with implications for the development of new treatments for chronic pain and cancer. The paper, “Structure of the full-length TRPV2 channel by cryo-EM,” was published in Nature Communications. Researchers led by Dr. Vera Moiseenkova-Bell had previously established the link between TRPV2’s molecular mechanism in a study published in December 2015 in Molecular and Cellular Biology, titled “Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling to Enhance Neurite Outgrowth in Developing Neurons.” Moiseenkova-Bell’s team’s lab is the first to accurately and fully model TRPV2’s structure. The group used neuronal cells to reveal the previously unidentified…
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Allodynia: Root of Chronic Pain Identified

Chronic Pain Conditions, Chronic Pain News
[caption id="attachment_769" align="alignleft" width="361"] NIPS-led researchers measured the heightened pain response when mice with a leg nerve injury were poked on the underside of a hind paw with a fine filament. Simultaneous live imaging of calcium ions in the brain's S1 cortex showed that certain signaling pathways were activated in astrocytes, a type of cell that helps neurons. Certain signaling pathways in S1 astrocytes were activated and triggered S1 cortex rewiring, contributing to mechanical hypersensitivity (allodynia). Such astrocyte-mediated changes in the brain may provide new clues for novel therapeutic strategies for treating debilitating mechanical allodynia.[/caption] Okazaki, Japan - When we are in pain, we reach for painkillers as we try to "turn off" the pain. Unfortunately, this does not always work, and this problem has prompted researchers around the world…
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Inherited Neuropathy: New Cause Identified

Chronic Pain Conditions, Chronic Pain News, Peripheral Neuropathy
Neurology researchers link mutations in myelin protein to Charcot-Marie-Tooth Disease, an inherited neuropathy. PHILADELPHIA - Charcot-Marie-Tooth Disease (CMT) is in the family of inherited neuropathy, of the peripheral nervous system, affecting approximately one in 2,500 Americans. Its most common iteration, CMT1, comes in many forms, most of which have to date been linked to a small set of causative genes. New research from the department of Neurology at the Perelman School of Medicine at the University of Pennsylvania and the Children's Hospital of Philadelphia recently spanned the globe to uncover a new genetic cause of CMT1. Their findings are published online this week in Brain. Their findings expand the number of genes known to cause CMT1, further helping neurologists and patients find the genetic underpinnings of their neuropathy. Charcot-Marie Tooth Disease…
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Nutrition and It’s Importance in Pain Management

Chronic Pain News, Lifestyle Tips for Chronic Pain
Nutrition is a critical, yet often overlooked, component of chronic pain management. Food choices—how you nourish your body—and the amount of food consumed can determine how you feel and how your body reacts. Many painful conditions (carpal tunnel syndrome, rheumatoid arthritis, osteoarthritis, lower back pain, fibromyalgia, gout, migraines, headaches and more) can be improved by choosing anti-inflammatory foods and spices. Chronic pain can make life seem out of one’s control; the ability to control pain through nutrition can be a powerful, useful tool. It’s important to note that individuals who are overweight typically suffer from increased pain levels and don’t receive the same degree of pain relief from the typical treatments and interventions as individuals that are of a healthy weight. DIET & PRESCRIPTION MEDICATION Many people living with chronic…
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Manipulation Under Anesthesia for Chronic Pain

Chronic Pain News
Manipulation under anesthesia (MUA) is a noninvasive stretching and manipulative technique. MUA may be performed to offer relief from chronic and recurrent back pain and other types of pain that have not responded to long-term conservative (ie, nonsurgical) care. MUA breaks up adhesions (internal scar tissue that can result from injury or surgery) and may help restore more normal range of motion and reduce pain. It is used to treat back, neck and joint pain, as well as muscle spasms and long-lasting pain syndromes. Adhesions can grow around spinal joints and nerve roots, and inside surrounding muscles, resulting in restricted movement, limited flexibility, and pain. A patient undergoing manipulation under anesthesia is sedated. While sedated, the patient is in a relaxed “twilight” state, similar to the sedation for a colonoscopy.…
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Central Nervous System May Contribute to DPN

Chronic Pain News, Peripheral Neuropathy
One of the key contributors to peripheral nerve disease in patients with diabetes is the central nervous system (CNS), a new report suggests. Published in the journal Pain, the study, conducted by Dr Solomon Tesfaye of Sheffield (UK) Teaching Hospitals NHS Foundation Trust and colleagues found changes within the central nervous system (CNS) were associated with the development of diabetic peripheral neuropathy (DPN), according to a press release. According to the release, about 25% of people with diabetes have symptoms of DPN, including progressive and severe pain and insensitivity to trauma, leading to an increased risk of foot ulcers, infections and amputation. "Although [diabetic peripheral neuropathy] has been considered a disease of the peripheral nerve, from numerous studies it is becoming apparent that there are indeed changes within the CNS that…
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Headache Relief Fast Tracked

Chronic Pain News, Therapies & Treatments
A migraine headache, tension headaches, sinus headaches, cervicogenic headaches, and ice cream headaches all have three things in common. Headaches never seem to end. Just as we wrap up one year the next years' nagging issues come back roaring headaches being one of them. Regardless of which type of headaches you get they are miserable. Some feel tension headaches are worse than migraines, while some commiserate that sinus headaches are the worst.The safest thing to understand is all headaches hurt. Alas help is on the horizon. A new headache treatment procedure that combines two particularly effective methods is showing promise. The relief is not in the form of a pill so you won't learn about it from advertising.Cold laser therapy has been used for a number of physical pain conditions.…
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Short Circuit Chronic Pain with Technology

Chronic Pain Conditions, Chronic Pain News
More than 100 million people in the United States have pain that won't go away. Many fail to get relief from pills, shots and surgery, while others trade the pain for side effects such as drowsiness or digestive problems. Unfortunately, too many become addicted to medications while trying to relieve their pain. As part of a comprehensive treatment plan, a variety of technologies offer new hope to people living with chronic illnesses. "Pain is one of the most challenging things to treat because its source can be elusive," says Richard Rosenquist, M.D., chair of the Committee on Pain Medicine and chairman of the department of pain management at the Anesthesiology Institute at the Cleveland Clinic. "That's why it's vital to see a physician specializing in pain medicine who can help identify…
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Mobile Health Apps Improve Diabetes Care

Chronic Pain News
In order to improve the quality of healthcare services and boost patient health outcomes, providers have begun adopting a variety of new technologies include mobile health apps, remote monitoring tools, and telemedicine systems. Chronic disease management is a major priority of the medical field today, as diabetes, heart disease, and various other illnesses compose a large part of healthcare spending. Mobile health apps and other mHealth technologies could help assist in strengthening chronic disease management strategies. The American Health Information Management Association’s (AHIMA) recently announced in a press release that using medical claims data and health informatics could potentially lead to the creation of effective, patient-centric mobile health apps meant to better manage chronic medical conditions. “As healthcare systems move from volume-based to value-based reimbursement models, providers are looking for…
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