Regenerative Biology: A New Molecule Regenerates Bone Tissue

Researchers from California discover the key to simplifying the creation of engineered bones: adenosine. This naturally occurring molecule can be injected into bone tissue to coax human pluripotent stem cells to regenerate. REGENERATING BONE TISSUE The incidence of bone disorders, particularly in populations where aging is tied to rising obesity rates and poor physical activity,…

Boost Immune System to Effect Repairs and Fight Disease

Applications from Regenerative Medicine to Gene Therapy to Antiviral Therapeutics Emphasize Self-Healing Therapeutic interventions of various kinds try to improve the body’s capacity to defend, repair, and even cure itself. Interventions that attempt to enhance self-healing span cell-based therapy, gene therapy, small molecule drugs, biologics, and tissue engineering. Advances in each of these areas are…

Food as medicine: importance of nutrition in disease

‘‘Get your health from the farm, not from the pharmacy.’’ That’s not necessarily what you’d expect to hear at an international conference attended by some of the biggest names in the world of medicine and nutrition. Nor do you expect this declaration to be received with clapping, whooping and cheering from a respectable crowd of…

Emotional Expression Benefits Chronic Pain

A therapeutic intervention involving confronting and expressing emotional and traumatic experiences shows greater improvement in fibromyalgia pain compared with conventional cognitive-behavioral therapy (CBT), randomized trial results show. It was also linked to significant pain reductions when offered as a one-time intervention in the primary care setting, researchers report. “Current evidence-based psychological interventions for fibromyalgia, such…

Buprenorphine Patches in Diabetic Peripheral Neuropathy

Transdermal buprenorphine may be an effective therapy for diabetic peripheral neuropathic pain (DPNP), however the treatment was associated with a high rate of adverse events, mostly nausea and/or vomiting. The findings come from a newly published multi-center, randomized, double-blind, placebo-controlled, parallel-group trial. Ninety-three patients with type 1 or 2 diabetes were enrolled and received either…

Tarantula toxin untangles pain pathways

A toxin isolated from the Togo starburst tarantula provides new insights into pain mechanisms and could lead to new treatments for irritable bowel syndrome. With their large, hairy bodies and long legs, tarantulas are an arachnophobe’s worst nightmare. For pain researchers, however, these outsized spiders are a dream come true: Their venom contains a cocktail…

Blocking Intracellular Glutamate May Halt Neuropathic Pain

Experiments to block receptors deep within spinal neurons, metabotropic glutamate 5 receptors (mGluR5), may open the door to more effective treatments for neuropathic pain. Understanding how the body processes pain is essential to understanding how to better treat it. Aiding in that understanding has been intense research on one of the key players that transmit…