Neuromodulation and Regenerative Medicine Advances

Highlights from the American Society of Interventional Physicians annual meeting, including neuromodulation, humanistic care, vertebral augmentation, regenerative medicine, controlled substance prescribing, and more. There are numerous medical conferences that Practical Pain Management (PPM) tries to attend and cover. We are fortunate that when the PPM staff can’t attend a conference, we usually can call upon one of our expert…

Neuroscientists Focus on Cell Mechanism That Promotes Chronic Pain

Researchers have discovered a new pain-signaling pathway in nerve cells that eventually could make a good target for new drugs to fight chronic pain. The findings, published in the journal PLoS Biology by a UT Dallas neuroscientist and his colleagues, suggest that inhibiting a process called phosphorylation occurring outside of nerve cells might disrupt pain signals, and…

Preventing Shingles in RA Patients

The live varicella-zoster vaccine can effectively prevent shingles in rheumatoid arthritis patients starting treatment with the drug tofacitinib, according to results of 2 recently-published studies in Arthritis & Rheumatology. Shingles causes a painful rash that may appear as a stripe of blisters on the trunk of the body. Pain can persist even after the rash is gone…

Integrating Stem Cells into Functional Neural Networks

The inherent potential of stem cells to engender any cellular form and function drives the field of regenerative medicine. In recent years, stem cell research has witnessed prolific growth particularly in disease-modeling, drug discovery and patient-specific cell therapy. A major challenge in stem cell-mediated therapy is to understand and promote integration of transplanted stem cells…

Vitamin B3 Reduces Pain From Chemo-Induced Peripheral Neuropathy

Nicotinamide riboside (NR), a type of vitamin B3, may prevent chemotherapy-induced peripheral neuropathy (CIPN), a recent study in animals has shown. Although chemotherapy increases survival rates, it can have serious side effects, including peripheral neuropathy, that affect quality of life.1 “Our findings support the idea that NR could potentially be used to prevent or mitigate…

Advancing Pain Management Medicine: Human Studies

Nearly every advance in modern medicine, from diagnosis to treatment, has benefited from animal studies. Basic research has made vital contributions to all aspects of medical care, including our understanding of pain pathophysiology. However, the applicability of these findings to humans remains limited. “Translation from animal to human is hindered by many obstacles, in particular…