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Experiments to block receptors deep within spinal neurons, metabotropic glutamate 5 receptors (mGluR5), may open the door to more effective treatments for neuropathic pain. Understanding how the body processes pain is essential to understanding how to better treat it. Aiding in that understanding has been intense research on one of the key players that transmit […]
Using patient-derived stem cells, researchers create laboratory neuron models that reflect a patient’s response to a pain drug. Pain can be tough to take, and it’s also difficult to study: rodent models for pain do not necessarily translate to human pain conditions and expression of disease-causing mutations in cell lines may not precisely mimic the
Researchers Map Full-length Protein Involved in Chronic Pain, with Hopes for Future Therapies Case Western Reserve University School of Medicine researchers have discovered the full-length structure of a protein named Transient Receptor Potential Vanilloid subtype 2 (TRPV2), with implications for the development of new treatments for chronic pain and cancer. The paper, “Structure of the full-length TRPV2 channel by
Okazaki, Japan – When we are in pain, we reach for painkillers as we try to “turn off” the pain. Unfortunately, this does not always work, and this problem has prompted researchers around the world to seek the “main switch” that can promptly and effectively conduct this switching off. Pain comes in many forms; one
Neurology researchers link mutations in myelin protein to Charcot-Marie-Tooth Disease, an inherited neuropathy. PHILADELPHIA – Charcot-Marie-Tooth Disease (CMT) is in the family of inherited neuropathy, of the peripheral nervous system, affecting approximately one in 2,500 Americans. Its most common iteration, CMT1, comes in many forms, most of which have to date been linked to a small
Nutrition is a critical, yet often overlooked, component of chronic pain management. Food choices—how you nourish your body—and the amount of food consumed can determine how you feel and how your body reacts. Many painful conditions (carpal tunnel syndrome, rheumatoid arthritis, osteoarthritis, lower back pain, fibromyalgia, gout, migraines, headaches and more) can be improved by
Manipulation under anesthesia (MUA) is a noninvasive stretching and manipulative technique. MUA may be performed to offer relief from chronic and recurrent back pain and other types of pain that have not responded to long-term conservative (ie, nonsurgical) care. MUA breaks up adhesions (internal scar tissue that can result from injury or surgery) and may
One of the key contributors to peripheral nerve disease in patients with diabetes is the central nervous system (CNS), a new report suggests. Published in the journal Pain, the study, conducted by Dr Solomon Tesfaye of Sheffield (UK) Teaching Hospitals NHS Foundation Trust and colleagues found changes within the central nervous system (CNS) were associated
A migraine headache, tension headaches, sinus headaches, cervicogenic headaches, and ice cream headaches all have three things in common. Headaches never seem to end. Just as we wrap up one year the next years’ nagging issues come back roaring headaches being one of them. Regardless of which type of headaches you get they are miserable.
More than 100 million people in the United States have chronic conditions that won’t go away. Many fail to get relief from pills, shots and surgery, while others trade the sensation for unwanted side effects. These side effects can include such things as drowsiness or digestive problems. Unfortunately, too many can become addicted to medications
