Diabetic Peripheral Neuropathy Management

Diabetic peripheral neuropathy affects approximately 60-70% of diabetic patients and a total of 347 million people worldwide.1 This complication is not only associated with painful symptoms, but can also lead to significant consequences such as paresthesia, loss of sensation, ulcers, osteomyelitis, gangrene, foot deformities, and amputation. Common symptoms of diabetic peripheral neuropathy are listed in Table 1. Because the symptoms and complications of diabetic peripheral neuropathy can lead to a significant decrease in a patient's quality of life, it is important to evaluate the effectiveness of the various treatment options available in the management of diabetic peripheral neuropathy. Unfortunately, treating…
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Allodynia: Root of Chronic Pain Identified

Okazaki, Japan - When we are in pain, we reach for painkillers as we try to "turn off" the pain. Unfortunately, this does not always work, and this problem has prompted researchers around the world to seek the "main switch" that can promptly and effectively conduct this switching off. Pain comes in many forms; one is allodynia, which is pain that is greatly amplified by even the slightest sensations, such as light, touch, or warmth. Current treatments to alleviate allodynia are limited. The spinal cord and glial cells, which provide support and insulation between neurons and are the most abundant…
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Manipulation Under Anesthesia for Chronic Pain

Manipulation under anesthesia (MUA) is a noninvasive stretching and manipulative technique. MUA may be performed to offer relief from chronic and recurrent back pain and other types of pain that have not responded to long-term conservative (ie, nonsurgical) care. MUA breaks up adhesions (internal scar tissue that can result from injury or surgery) and may help restore more normal range of motion and reduce pain. It is used to treat back, neck and joint pain, as well as muscle spasms and long-lasting pain syndromes. Adhesions can grow around spinal joints and nerve roots, and inside surrounding muscles, resulting in restricted…
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