Prediabetes in Peripheral Neuropathy

Peripheral neuropathy may be more common in patients with prediabetes than previously thought, and early interventions may be warranted in this patient population, according to researchers from the University of Utah. Currently, 86 million adults, more than one in three U.S. adults, have prediabetes, according to CDC estimates. Without weight loss and moderate physical activity, 15% to 30% of these people will develop full-blown type 2 diabetes within 5 years.1 These numbers emphasize the urgent need to treat and prevent the subsequent complications, including neuropathy, associated with prediabetes. Fortunately, researchers are on their way to learning more about the relationship…
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The Four Types of Diabetic Neuropathy

Most of us associate peripheral neuropathy with diabetes. What might be a surprise is that there are three other forms of neuropathy that are also common to diabetics. Diabetic neuropathy is the result of prolonged periods of excess glucose in the blood damaging fragile nerve fibers. Hyperglycemia also damages the walls of the many blood vessels in the body, including the capillaries that provide the blood supply that supports the nervous system. Finally, high glucose levels interfere with the ability of the nerves to send signals. Taken together, this triad of damage causes first numbness, then extreme pain, in the…
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Peripheral Arterial Disease can cause Leg Pain

ST. PAUL, Minn.--(BUSINESS WIRE)--September marks peripheral arterial disease (PAD) awareness month. A staggering 18 million Americans1 suffer from this potentially life threatening disease which is greater than the number of Americans suffering from stroke (6.8 million)2, cancer (13 million)3, and coronary artery disease (16.3 million)4. If untreated, those who suffer from PAD are at risk of very serious consequences. The five-year mortality rate is 30 percent5, which is greater than the rates for prostate cancer (less than 1 percent)6 and breast cancer (11 percent)7. For the nearly 3.5 million people who suffer from the worst form of PAD, called critical…
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Electrical Nerve Stimulation Device Prevents Migraine

Study shows 81% reduction in number of migraine days per month with electrical nerve stimulation In a new study, Cefaly, the first FDA-approved transcutaneous electrical nerve-stimulation device for use before onset of migraine pain. It was shown to have provided relief for 81% of migraine patients who used it. The study, conducted in Italy, enrolled 24 patients with migraine without aura. These patients were experiencing a low number of attacks per month and who had taken migraine-preventive drugs. The primary outcome measures were the reductions in migraine attacks and in the number of migraine days per month. Then investigators also…
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Disturbed Sleep: Causes and Treatments

In the Diagnostic and Statistical Manual of Mental Disorders 5, sleep-wake disorders encompass 10 conditions manifested by disturbed sleep, distress, and impairment in daytime functioning.1 Sleep disorders include insomnia, narcolepsy, restless leg syndrome, and breathing-related disorders (obstructive sleep apnea). Excessive daytime sleepiness, or sudden somnolence, is a symptom that can occur with several sleep disorders. Excessive daytime sleepiness may include mild sleepiness, unrecognized episodes of “micro-sleep” or uncontrolled sleep attacks that result in falling asleep while in conversation, reading or watching television, or even while driving. Excessive daytime sleepiness may be caused by not getting enough hours of sleep or…
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How to Treat Back Pain without Drugs

Back pain is a common health issue today that affects at least eight out of 10 people. It is a prevalent problem among Americans. In fact, statistics from the American Chiropractic Association (ACA) reveal that at least 31 million Americans experience lower back pain at any given time. The ACA report also says that: One-half of all working Americans admit to having back pain symptoms each year. Back pain is one of the most common reasons for missed work. In fact, it is the second most common reason for visits to the doctor’s office (next to upper-respiratory infections). As many…
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10 Questions Neuropathy Patients Should Ask Their Doctor

If you’re meeting with your doctor or neurologist for the first time to discuss your neuropathy like symptoms – such as pain, numbness or tingling in the hands or feet – your mind is likely swirling with questions, concerns, what-ifs and more. Taking the time beforehand to write down a list of questions or concerns you wish to discuss can have a significant impact not only on your peace of mind – but also on your chances of receiving the best advice and care possible for your own unique circumstances. Asking the right questions can help both you and your…
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Neuropathy 10 Things You Need to Know

Life with neuropathy can be filled with unknowns – especially for those of us whose symptoms or diagnoses are relatively new. Navigating this new life with a painful condition can be (and most often is) overwhelming and frustrating. From bothersome symptoms like lack of muscle control to debilitating ones such as sharp, stabbing pains in the hands or feet, it can wreak havoc on your quality of life. Finding out as much information as possible about the condition, its causes and its treatments can go a long way in getting you onto the path to a better – and more pain…
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Diabetic Neuropathy: Temporarily Reducing Pain

Painful diabetic neuropathy (PDN) can be relieved for months with a non-viral gene therapy, according to research published in the Annals of Clinical and Translational Neurology. Researchers from Northwestern Medicine administered the non-viral gene therapy or a placebo in order to evaluate the safety and efficacy of a plasmid (VM202) containing 2 human hepatocyte growth factor isoforms given by intramuscular injections in patients with PDN. There were 84 patients included in the study who were randomized to either receive injections of 8 or 16 mg VM202 per leg or placebo. Doses were administered on days zero and 14. The researchers…
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Spinal Cord Cells Control Pain

Spinal cord cells are responsible for controlling pain and itch, according to research published in the journal Neuron. Researchers from the University of Zurich used genetically modified viruses to interfere with the functions of neurons in mice in order to investigate how neurons contribute to pain and itch processing. The researchers drew on prior findings from 50 years ago, which had demonstrated “Gate Control Theory” of pain – the idea that inhibitory nerve cells in the spinal cord could determine whether a pain impulse from the periphery (from the foot, for example) is relayed to the brain or suppressed. The…
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