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Nearly every advance in modern medicine, from diagnosis to treatment, has benefited from animal studies. Basic research has made vital contributions to all aspects of medical care, including our understanding of pain pathophysiology. However, the applicability of these findings to humans remains limited. “Translation from animal to human is hindered by many obstacles, in particular […]
Diabetic peripheral neuropathy affects approximately 60-70% of diabetic patients and a total of 347 million people worldwide.1 This complication is not only associated with painful symptoms, but can also lead to significant consequences such as paresthesia, loss of sensation, ulcers, osteomyelitis, gangrene, foot deformities, and amputation. Common symptoms of diabetic peripheral neuropathy are listed in
Dr. Brian M. Ilfeld, MD, MS, feels this strongly about the potential for ultrasound-guided percutaneous peripheral nerve stimulation. It’s a technology that he says has the potential to forever change the way anesthesiologists treat acute postoperative pain. He discussed the results of a prospective feasibility study. As well as the potential for the technology’s future—at
Experiments to block receptors deep within spinal neurons, metabotropic glutamate 5 receptors (mGluR5), may open the door to more effective treatments for neuropathic pain. Understanding how the body processes pain is essential to understanding how to better treat it. Aiding in that understanding has been intense research on one of the key players that transmit
Neurology researchers link mutations in myelin protein to Charcot-Marie-Tooth Disease, an inherited neuropathy. PHILADELPHIA – Charcot-Marie-Tooth Disease (CMT) is in the family of inherited neuropathy, of the peripheral nervous system, affecting approximately one in 2,500 Americans. Its most common iteration, CMT1, comes in many forms, most of which have to date been linked to a small
In patients with painful diabetic neuropathy, a single high-dose intramuscular injection of vitamin D appears to confer a significant reduction in symptoms, according to study data. Rayaz A. Malik, MBChB, PhD, professor of medicine at Weill Cornell Medicine in Qatar, and colleagues evaluated 143 adults (mean age, 52 years) with type 1 or type 2
One of the key contributors to peripheral nerve disease in patients with diabetes is the central nervous system (CNS), a new report suggests. Published in the journal Pain, the study, conducted by Dr Solomon Tesfaye of Sheffield (UK) Teaching Hospitals NHS Foundation Trust and colleagues found changes within the central nervous system (CNS) were associated
If you’re looking for an alternative to pain medication, reflexology may be an option. Find out if you could benefit from this form of massage. Sometimes pain therapy can be downright relaxing. Although getting a massage may conjure up the image of a spa rather than a medical office, reflexology, which involves the placement of
Psychologists are exploring complementary therapies and integrated approaches to better treat the complex problem of chronic pain. If cancer is “the emperor of all maladies,” as physician and author Siddhartha Mukherjee wrote, chronic pain may be the empress, affecting 100 million people in the United States and costing up to $630 billion each year in
Peripheral nerve stimulation (PNS) is an effective long-term treatment for managing chronic intractable headaches, suggests research published in Pain Physician. In this retrospective study, peripheral nerve stimulation reduced mean headache severity on the 11-point Numeric Rating Schedule (NRS) by nearly 50% within one-month post implantation. After 12 months, headache severity scores decreased by at least 50%
