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Researchers have discovered a new pain-signaling pathway in nerve cells that eventually could make a good target for new drugs to fight chronic pain. The findings, published in the journal PLoS Biology by a UT Dallas neuroscientist and his colleagues, suggest that inhibiting a process called phosphorylation occurring outside of nerve cells might disrupt pain signals, and […]
Neurobiologist Clifford Woolf discusses the importance of pain points and the surprising twists of his latest research Pain—feared, misunderstood and even poeticized in works of art and literature—has long captivated the scientific imagination of Clifford Woolf since his days as a medical student in South Africa. Woolf, a Harvard Medical School professor of neurobiology and neurology at
A study led by Columbia University Medical Center (CUMC) has shown that chronic pain may occur when pain receptors migrate from the nerve cell’s surface to the cell’s inner chambers, out of the reach of current pain medications. The discovery, in rodents, may lead to the development of a new class of medications for chronic
This article is part of Endocrinology Advisor’s coverage of the American Diabetes Association’s 77th Scientific Sessions (ADA 2017), taking place in San Diego, CA. Our staff will report on medical research and technological advances in diabetes and diabetes education, conducted by experts in the field. Check back regularly for more news from ADA 2017. Results
Abstract and Introduction Abstract Microvascular complications of diabetes include eye disease, kidney disease, and peripheral and/or autonomic neuropathy. This study illustrates the importance of early screening and detection of microvascular complications, while also focusing on treatment guidelines and indications for specialist referral. Introduction Diabetes mellitus (DM) is a chronic disease that is classified, based on
Functional abdominal pain syndrome (FAPS) is a functional gastrointestinal disorder, which involves chronic or frequent pain that does not result from a specific, identifiable cause. Symptoms The primary symptom of FAPS is abdominal pain. The pain can often be very severe and impact the quality of life of patients significantly. This can even disrupt their
The distinction between a headache and a migraine can be hard to define. For those who have never been affected, the distinction between a headache and migraines can be hard to define. Headaches affect the head, are caused by stress, exhaustion, et cetera, and are painful [1]. Migraines are a type of headache that display
That a finger can distinguish the texture of satin from suede is an exquisite sensory discrimination. Largely relying on small sensory organs in the fingertips called Merkel discs containing Merkel Cells. Jianguo Gu, Ph.D., of the University of Alabama at Birmingham, has now unraveled how the sensory information is processed in the Merkel discs. As
Researchers from California discover the key to simplifying the creation of engineered bones: adenosine. This naturally occurring molecule can be injected into bone tissue to coax human pluripotent stem cells to regenerate. REGENERATING BONE TISSUE The incidence of bone disorders, particularly in populations where aging is tied to rising obesity rates and poor physical activity.
Visceral pain relates to pain in the organs of the body. So it could be the chest, or more likely, the abdomen or the pelvis. It is somewhat unlike other pain syndromes. In a sense that visceral pain activates the autonomic nervous system, specifically the parasympathetic nervous system, the sympathetic nervous system, or both. Which
