08 Aug 2016
By webadmin@macmdaz.com

Hamstring Tendinopathy

Chronic Pain Conditions
Athletes who complain of deep buttock pain and pain when sitting may have hamstring tendinopathy. Playser with deep, posterior, upper thigh pain may be suffering from high (proximal) hamstring tendon injury as well. Chronic high hamstring tendinopathy is becoming increasing recognized as a causative factor in both sitting and activity-related posterior hip pain.1,2,3 Unlike an acute tear, the pain usually comes on gradually and may be aggravated by repetitive activities. Such activities as running or biking, and worsened by prolonged sitting. How Does Hamstring Tendinopathy Pain Develop? The body has many tendons, which anatomically are fibrous tissues that connect muscle…
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04 Jul 2016
By webadmin@macmdaz.com

Manufactured Stem Cells Might Boost New Diabetes Therapies

Chronic Pain Conditions, Regenerative medicine, Therapies & Treatments, , , ,
Induced pluripotent stem cells (iPSCs) can be generated from adult cells. iPSCs have the potential to develop into any cell type in the human body. These cells hold an enormous therapeutic potential in a variety of conditions. Including but not limited to cardiac diseases, Alzheimer’s, Parkinson’s disease, spinal cord injury, and diabetes. A team of researchers from Lonza, developed clinical-grade iPSCs from human umbilical cord blood cells collected following a healthy birth. These cells, described in the study “cGMP-Manufactured Human Induced Pluripotent Stem Cells Are Available for Pre-Clinical and Clinical Applications,” published in Stem Cell Reports. iPSCs are now available for…
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27 Jun 2016
By webadmin@macmdaz.com

Buprenorphine Patches in Diabetic Peripheral Neuropathy

Chronic Pain Conditions, Chronic Pain News, Nerve Pain, ,
Transdermal buprenorphine may be an effective therapy for diabetic peripheral neuropathic pain (DPNP). However the treatment was associated with a high rate of adverse events, mostly nausea and/or vomiting. The findings come from a newly published multi-center, randomized, double-blind, placebo-controlled, parallel-group trial. Ninety-three patients with type 1 or 2 diabetes were enrolled and received either buprenorphine (5μg/h) or placebo patches. All the patients had been experiencing moderate to severe DPNP for a minimum of 6 months on maximal tolerated conventional therapy. The dose was titrated to effect to a maximum of 40μg/h for the study. Results showed that of those…
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20 Jun 2016
By webadmin@macmdaz.com

Sacral Neuromodulation for Sacrectomy Patients

Chronic Pain Conditions, Spinal Cord Stimulation, Therapies & Treatments, , ,
Sacral chordoma is a rare malignant tumor arising from remnants of the notochord. Due to its propensity for recurrence, the treatment of choice is surgical resection. Orthopedic and neurosurgical literature describe bladder dysfunction as prevalent in these patients, specifically urinary incontinence, however urologic literature is lacking in the exact nature of this dysfunction. Thus far, Sacral Nerve Stimulation (SNS) has not been described as a treatment option for these patients. We describe a 36-year-old female who underwent midsacral resection (S3 and below) for a sacrococcygeal chordoma. She suffered from postoperative urinary incontinence and incomplete emptying requiring intermittent catheterization. Urodynamic evaluation…
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09 May 2016
By webadmin@macmdaz.com

Full-length Protein Involved in Chronic Pain

Chronic Pain Conditions, Chronic Pain News, , , ,
Researchers Map Full-length Protein Involved in Chronic Pain, with Hopes for Future Therapies Case Western Reserve University School of Medicine researchers have discovered the full-length structure of a protein named Transient Receptor Potential Vanilloid subtype 2 (TRPV2), with implications for the development of new treatments for chronic pain and cancer. The paper, “Structure of the full-length TRPV2 channel by cryo-EM,” was published in Nature Communications. Researchers led by Dr. Vera Moiseenkova-Bell had previously established the link between TRPV2’s molecular mechanism in a study published in December 2015 in Molecular and Cellular Biology, titled “Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling…
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25 Apr 2016
By webadmin@macmdaz.com

Allodynia: Root of Chronic Pain Identified

Chronic Pain Conditions, Chronic Pain News, , ,
Okazaki, Japan - When we are in pain, we reach for painkillers as we try to "turn off" the pain. Unfortunately, this does not always work, and this problem has prompted researchers around the world to seek the "main switch" that can promptly and effectively conduct this switching off. Pain comes in many forms; one is allodynia, which is pain that is greatly amplified by even the slightest sensations, such as light, touch, or warmth. Current treatments to alleviate allodynia are limited. The spinal cord and glial cells, which provide support and insulation between neurons and are the most abundant…
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18 Apr 2016
By webadmin@macmdaz.com

Phantom Limb Pain: Causes, Symptoms & Treatment

Chronic Pain Conditions, , , ,
Phantom limb pain (PLP) is described as mild to extreme pain in an amputated limb. It was previously thought as a psychological response of patients who underwent amputation, but recent studies reveal scientific evidence of pain sensation that originates from the brain and spinal cord. Although phantom limb pain is often seen in patients with amputated limbs, other individuals who underwent surgical removal of other body parts, such as eye, penis, and breast also complain of the pain sensation. What Are The Causes Phantom Limb Pain? Even if the limb is no longer present, the nerve endings found at the…
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11 Apr 2016
By webadmin@macmdaz.com

Inherited Neuropathy: New Cause Identified

Chronic Pain Conditions, Chronic Pain News, Peripheral Neuropathy, , , , ,
Neurology researchers link mutations in myelin protein to Charcot-Marie-Tooth Disease, an inherited neuropathy. PHILADELPHIA - Charcot-Marie-Tooth Disease (CMT) is in the family of inherited neuropathy, of the peripheral nervous system, affecting approximately one in 2,500 Americans. Its most common iteration, CMT1, comes in many forms, most of which have to date been linked to a small set of causative genes. New research from the department of Neurology at the Perelman School of Medicine at the University of Pennsylvania and the Children's Hospital of Philadelphia recently spanned the globe to uncover a new genetic cause of CMT1. Their findings are published online…
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25 Jan 2016
By webadmin@macmdaz.com

Nervous System Triggers Pain Sensation

Chronic Pain Conditions, Nerve Pain, , ,
Pain is a sensation that is triggered in the nervous system. It can be sharp or dull and last for short or long periods. Pain may be localized to a specific area of the body such as the abdomen, chest or back or it can be felt all over the body, such as when a person experiences all over muscle ache as a result of flu. Pain serves as a warning that something is wrong and can help in diagnosing a problem. Without pain, a person would be unaware that they had hurt themselves or that they have a medical…
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04 Jan 2016
By webadmin@macmdaz.com

Degenerative Disc Disease: What is it & how is it treated?

Chronic Pain Conditions, Nerve Pain, Therapies & Treatments, , ,
What is Degenerative Disc Disease? Degenerative Disc Disease (or DDD) is caused by degeneration of the discs in the spinal column. Age can cause this, but most of the time it is cause by some sort of trauma to the spine. People with bulging or herniated disc almost always have this disease, as well as people with Scoliosis. Symptoms range from person to person as well as the particular location of the spinal injury. People with lower back injuries can experience numbness and tingling in the legs and buttocks. The symptoms can also get as severe as temporary paralysis in…
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