Pain Points

Neurobiologist Clifford Woolf discusses the importance of pain points and the surprising twists of his latest research Pain—feared, misunderstood and even poeticized in works of art and literature—has long captivated the scientific imagination of Clifford Woolf since his days as a medical student in South Africa. Woolf, a Harvard Medical School professor of neurobiology and neurology at Boston Children’s Hospital, has been on a quest to understand the basic mechanisms of pain and to help spark the development of more effective therapies to alleviate pain points, especially ones that don’t have the abuse potential of opioids. Woolf is the senior author of…
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Full-length Protein Involved in Chronic Pain

Researchers Map Full-length Protein Involved in Chronic Pain, with Hopes for Future Therapies Case Western Reserve University School of Medicine researchers have discovered the full-length structure of a protein named Transient Receptor Potential Vanilloid subtype 2 (TRPV2), with implications for the development of new treatments for chronic pain and cancer. The paper, “Structure of the full-length TRPV2 channel by cryo-EM,” was published in Nature Communications. Researchers led by Dr. Vera Moiseenkova-Bell had previously established the link between TRPV2’s molecular mechanism in a study published in December 2015 in Molecular and Cellular Biology, titled “Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling…
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Nervous System Triggers Pain Sensation

Pain is a sensation that is triggered in the nervous system. It can be sharp or dull and last for short or long periods. Pain may be localized to a specific area of the body such as the abdomen, chest or back or it can be felt all over the body, such as when a person experiences all over muscle ache as a result of flu. Pain serves as a warning that something is wrong and can help in diagnosing a problem. Without pain, a person would be unaware that they had hurt themselves or that they have a medical…
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Chronic Pain: 6 Surprising Triggers

The causes of chronic pain can be deep-seated, emotional, and even as basic as a really bad diet. There's nothing worse than suffering from debilitating chronic pain—except, perhaps, not knowing why you're in pain or how to cope. Treating these mysterious aches has become the mission of Gary Kaplan, DO, a pioneer of integrative medicine and director of the Kaplan Clinic for Integrative Medicine in McLean, Virginia. He treats people with chronic pain every day. In Kaplan's new book, Total Recovery: Breaking the Cycle of Chronic Pain and Depression, he addresses the root causes of chronic pain, and how most…
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