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Long-term uncontrolled glycemic levels primary cause of complication in diabetes, such as diabetic peripheral neuropathy. There is a gradual increase in incidence of type 1 diabetes (T1D) and type 2 diabetes (T2D) among the U.S. youth population. Studies show that if this continues, diabetes prevalence among the youth population will triple within three decades. One […]
Diabetic peripheral neuropathy affects approximately 60-70% of diabetic patients and a total of 347 million people worldwide.1 This complication is not only associated with painful symptoms, but can also lead to significant consequences such as paresthesia, loss of sensation, ulcers, osteomyelitis, gangrene, foot deformities, and amputation. Common symptoms of diabetic peripheral neuropathy are listed in
In patients with painful diabetic neuropathy, a single high-dose intramuscular injection of vitamin D appears to confer a significant reduction in symptoms, according to study data. Rayaz A. Malik, MBChB, PhD, professor of medicine at Weill Cornell Medicine in Qatar, and colleagues evaluated 143 adults (mean age, 52 years) with type 1 or type 2
One of the key contributors to peripheral nerve disease in patients with diabetes is the central nervous system (CNS), a new report suggests. Published in the journal Pain, the study, conducted by Dr Solomon Tesfaye of Sheffield (UK) Teaching Hospitals NHS Foundation Trust and colleagues found changes within the central nervous system (CNS) were associated
Peripheral neuropathy is a debilitating condition for which there are few effective treatments, mainly because we do not fully understand the underlying molecular mechanisms, say researchers whose latest discovery appears to shed new light in this area. The team, from McGill University in Montreal, Canada, reports the discovery in The Journal of Neuroscience. They hope
Severe, uncontrolled pain may exhaust the adrenal gland, resulting in low levels of pregnenolone and cortisol. While adequate pain control will usually normalize serum hormone levels, opioid-induced suppression of the system may require additional treatment. The effect of severe, persistent pain on the hormone system is profoundly negative.1-5 If the patient’s hormone system is not
Most of us associate peripheral neuropathy with diabetes. What might be a surprise is that there are three other forms of neuropathy that are also common to diabetics. Diabetic neuropathy is the result of prolonged periods of excess glucose in the blood damaging fragile nerve fibers. Hyperglycemia also damages the walls of the many blood
