Regenerative Medicine the Pain Management Alternative

Injuries happen to almost everyone, but for some they can be far worse. For those with chronic pain, arthritis and a host of other ailments, it can mean a lifetime of discomfort. While many of those symptoms can be treated, it’s often with invasive surgery or only partially effective treatments like cortisone shots. Regenerative medicine offers an alternative to going under the knife, while achieving lasting results. Relievus, a pain management and neurology specialist practice, offers these treatments at both its Havertown and Philadelphia locations. Here, clinician Dr. Uplekh Purewal offers insight. Q: What is regenerative medicine? A: It’s a form…
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Skin Cells may help repair MS damage

A personalized treatment for multiple sclerosis may be one step closer, thanks to a new study that reveals how a person's own skin cells could be used to repair the nerve damage that the disease causes. Led by scientists at the University of Cambridge in the United Kingdom, the study took skin cells from adult mice with multiple sclerosis (MS) and then reprogramed them into neural stem cells (NSCs). These "induced neural stem cells" (iNSCs) were transplanted into the rodents' cerebrospinal fluid. There, they reduced inflammation and repaired damage to the central nervous system (CNS). Lead study author Dr. Stefano Pluchino, of the Department of Clinical Neurosciences at…
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The Pain Signal Effect and the Body’s Response

Pain sends a signal that the body needs protection and healing. However, if the physiological changes triggered by it persists, harm will ensue, and acute pain may become chronic. So pain signal must be contained and/or relieved. The mechanisms through which pain interacts with the body provide health professionals with various routes of entry and intervention modes. This article discusses the intricacies of the adaptive response to pain and how they can be used to combat it. Citation: Swift A (2018) Understanding pain and the human body’s response to it. Nursing Times[online]; 114: 3, 22-26 Author: Amelia Swift is senior lecturer in nursing,…
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Radiculopathy

Radiculopathy is a medical term used to depict certain issues initiating in the spinal region, at the area of the nerve roots. It is a condition, which is a consequence of the pressure that is being begun from the herniated plate. However, there can be any other different cause to it. The pressure applied by the degenerative changes in the spine can likewise prompt pain in the back. These progressions prompt aggravation and bothering in the underlying foundations (roots) of the nerves. The nerves that are normally influenced by this issue are the sensory nerve. Thus, therefore, those muscles that…
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Muscle Stem Cells could Address Circulation Problems

CHAMPAIGN, Ill. -- Stem cells taken from muscle tissue could promote better blood flow in patients with diabetes who develop peripheral artery disease, a painful complication that can require surgery or lead to amputation. A new study in mice at the University of Illinois found that an injection of the stem cells prompted new blood vessels to grow, improving circulation in the affected tissues and function in the affected limbs. The stem cells also induced changes in gene expression in the surrounding tissues, prompting the release of factors to reduce inflammation and increase circulation. The study was published in the…
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Healing molecule discovery could reduce limb amputations

Scientists have discovered new insights into a molecule which is part of the body's tissue repair system, in a finding which could help treat non-healing wounds and injuries, such as diabetic foot body's tissue repair system, in a finding which could help treat non-healing wounds and injuries, such as diabetic foot. The number of limbs amputated because of diabetes is at an all-time high of 20 each day in England alone. Intense research around the world is being carried out to discover new treatments that could help avoid such life-changing operations and reduce medical costs for society. A study led…
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Nerve cell therapy restores motor function

Regenerative therapy using millions of nerve cells, derived from human embryonic stem cells, restored two or more motor levels on at least one side, in four out of six patients with paralyzing spinal cord injuries, according to researchers at the Rush University Medical Center in Chicago. In a press release, the medical center reported the 67% recovery rate is “more than double” the rates previously reported in matched historical controls and in published data in a similar population — patients who had lost all motor function below the location of their spinal injury. “Having worked on this research for more…
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Multivitamins May Reduce CIPN

Women who take multivitamin supplements before their breast cancer diagnosis and during chemotherapy appear to be less likely to develop the debilitating, often long-lasting symptoms of chemotherapy-induced peripheral neuropathy (CIPN), according to a new study.   In a large study of breast cancer patients undergoing paclitaxel chemotherapy, those who used multivitamins were about 40% less likely to suffer sensory loss. The researchers published their results online ahead of print in the Journal of the National Cancer Institute. “Our study showed that use of multivitamin supplements, but not specific vitamins, was associated with less neurotoxicity. This was true for use before diagnosis and, to…
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Shingles Pain Cause Discovered

It is very likely that when you were a child, you had chickenpox, a mostly benign condition that despite making you extremely itchy, required you to miss a week or two of school. While most parents would think their children are safe from the infection after its resolved, what they don’t realize is that it may show up later in life in a painful form called shingles. A constant feature of shingles is neuralgia—intense pain affecting mainly the nerves of the chest and neck, the trigeminal nerve in the fact, and the lower back. New research out of the University of…
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Neuroscientists Focus on Cell Mechanism That Promotes Chronic Pain

Researchers have discovered a new pain-signaling pathway in nerve cells that eventually could make a good target for new drugs to fight chronic pain. The findings, published in the journal PLoS Biology by a UT Dallas neuroscientist and his colleagues, suggest that inhibiting a process called phosphorylation occurring outside of nerve cells might disrupt pain signals, and provide an alternative to opioid drugs for alleviating chronic pain. Dr. Ted Price, the study’s co-author and associate professor of neuroscience in the School of Behavioral and Brain Sciences at UT Dallas, said the finding is significant. “We found a key new signaling pathway that can be managed,” Price…
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