The Pain Effect and the Body’s Response

Chronic Pain Conditions, Chronic Pain News, Nerve Pain
Pain sends a signal that the body needs protection and healing. However, if the physiological changes triggered by it persists, harm will ensue, and acute pain may become chronic, so pain must be contained and/or relieved. The mechanisms through which pain interacts with the body provide health professionals with various routes of entry and modes of intervention. This article discusses the intricacies of the adaptive response to pain and how they can be used to combat it. Citation: Swift A (2018) Understanding pain and the human body’s response to it. Nursing Times[online]; 114: 3, 22-26 Author: Amelia Swift is senior lecturer in nursing, University of Birmingham. She has updated a 2003 article, Understanding the physiological effects of unrelieved pain, written by Carolyn Middleton, clinical nurse specialist at Gwent Healthcare Trust. Introduction Pain, which…
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Radiculopathy

Chronic Pain Conditions, Nerve Pain
Radiculopathy is a medical term used to depict certain issues initiating in the spinal region, at the area of the nerve roots. It is a condition, which is a consequence of the pressure that is being begun from the herniated plate. However, there can be any other different cause to it. The pressure applied by the degenerative changes in the spine can likewise prompt pain in the back. These progressions prompt aggravation and bothering in the underlying foundations (roots) of the nerves. The nerves that are normally influenced by this issue are the sensory nerve. Thus, therefore, those muscles that have an immediate contact with the influenced sensory nerve roots have a tendency to get debilitated. Moreover, other than this, the quantity of roots that get influenced by this issue…
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Muscle Stem Cells could Address Circulation Problems

Chronic Pain Conditions, Chronic Pain News, Nerve Pain
CHAMPAIGN, Ill. -- Stem cells taken from muscle tissue could promote better blood flow in patients with diabetes who develop peripheral artery disease, a painful complication that can require surgery or lead to amputation. A new study in mice at the University of Illinois found that an injection of the stem cells prompted new blood vessels to grow, improving circulation in the affected tissues and function in the affected limbs. The stem cells also induced changes in gene expression in the surrounding tissues, prompting the release of factors to reduce inflammation and increase circulation. The study was published in the journal Theranostics. "PAD is very common in diabetic patients, but it is difficult to diagnose because patients experience symptoms when the disease is already at an advanced state," said study leader…
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Healing molecule discovery could reduce limb amputations

Chronic Pain News, Nerve Pain
Scientists have discovered new insights into a molecule which is part of the body's tissue repair system, in a finding which could help treat non-healing wounds and injuries, such as diabetic foot body's tissue repair system, in a finding which could help treat non-healing wounds and injuries, such as diabetic foot. The number of limbs amputated because of diabetes is at an all-time high of 20 each day in England alone. Intense research around the world is being carried out to discover new treatments that could help avoid such life-changing operations and reduce medical costs for society. A study led by the universities of Exeter and Bath, and published in the journal Antioxidants and Redox Signalling has made great strides in understanding how the molecule deoxyribose-1-phosphate stimulates the formation of new blood…
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Nerve cell therapy restores motor function

Chronic Pain News, Nerve Pain, Therapies & Treatments
Regenerative therapy using millions of nerve cells, derived from human embryonic stem cells, restored two or more motor levels on at least one side, in four out of six patients with paralyzing spinal cord injuries, according to researchers at the Rush University Medical Center in Chicago. In a press release, the medical center reported the 67% recovery rate is “more than double” the rates previously reported in matched historical controls and in published data in a similar population — patients who had lost all motor function below the location of their spinal injury. “Having worked on this research for more than 20 years, and given that we hadn’t seen any significant improvement before, these results are beyond anything I would have hoped for in the study,” researcher Richard G. Fessler, MD,…
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Multivitamins May Reduce CIPN

Chronic Pain Conditions, Chronic Pain News, Nerve Pain
Women who take multivitamin supplements before their breast cancer diagnosis and during chemotherapy appear to be less likely to develop the debilitating, often long-lasting symptoms of chemotherapy-induced peripheral neuropathy (CIPN), according to a new study.   In a large study of breast cancer patients undergoing paclitaxel chemotherapy, those who used multivitamins were about 40% less likely to suffer sensory loss. The researchers published their results online ahead of print in the Journal of the National Cancer Institute. “Our study showed that use of multivitamin supplements, but not specific vitamins, was associated with less neurotoxicity. This was true for use before diagnosis and, to a lesser extent, during chemotherapy,” said senior author Christine Ambrosone, PhD, of the Roswell Park Cancer Institute in Buffalo, New York. CIPN symptoms often persist after completion of chemotherapy, and…
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Shingles Pain Cause Discovered

Chronic Pain Conditions, Chronic Pain News, Nerve Pain
It is very likely that when you were a child, you had chickenpox, a mostly benign condition that despite making you extremely itchy, required you to miss a week or two of school. While most parents would think their children are safe from the infection after its resolved, what they don’t realize is that it may show up later in life in a painful form called shingles. A constant feature of shingles is neuralgia—intense pain affecting mainly the nerves of the chest and neck, the trigeminal nerve in the fact, and the lower back. New research out of the University of São Paulo (USP) has discovered why shingles patients feel pain, which lays the foundation for treating the condition. The same childhood virus Shingles occur due to the exact same virus that…
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Neuroscientists Focus on Cell Mechanism That Promotes Chronic Pain

Chronic Pain Conditions, Chronic Pain News, Nerve Pain, Therapies & Treatments
Researchers have discovered a new pain-signaling pathway in nerve cells that eventually could make a good target for new drugs to fight chronic pain. [caption id="attachment_1213" align="alignleft" width="383"] Neuroscientists Focus on Cell Mechanism That Promotes Chronic Pain[/caption] The findings, published in the journal PLoS Biology by a UT Dallas neuroscientist and his colleagues, suggest that inhibiting a process called phosphorylation occurring outside of nerve cells might disrupt pain signals, and provide an alternative to opioid drugs for alleviating chronic pain. Dr. Ted Price, the study’s co-author and associate professor of neuroscience in the School of Behavioral and Brain Sciences at UT Dallas, said the finding is significant. “We found a key new signaling pathway that can be managed,” Price said. “Now we hope we can use the findings to discover a new drug.” Phosphorylation is a…
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Preventing Shingles in RA Patients

Chronic Pain News, Nerve Pain, Therapies & Treatments
The live varicella-zoster vaccine can effectively prevent shingles in rheumatoid arthritis patients starting treatment with the drug tofacitinib, according to results of 2 recently-published studies in Arthritis & Rheumatology. Shingles causes a painful rash that may appear as a stripe of blisters on the trunk of the body. Pain can persist even after the rash is gone (this is called postherpetic neuralgia). Treatments include pain relief and antiviral medications such as acyclovir or valacyclovir. A chickenpox vaccine in childhood or a shingles vaccine as an adult can minimize the risk of developing shingles. Patients who received the shingles vaccine several weeks prior to the start of treatment for arthritis with tofacitinib demonstrated robust immune responses that were sustained even after the start of treatment. The researchers conducted 2 studies to evaluate the…
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Integrating Stem Cells into Functional Neural Networks

Chronic Pain News, Nerve Pain
The inherent potential of stem cells to engender any cellular form and function drives the field of regenerative medicine. In recent years, stem cell research has witnessed prolific growth particularly in disease-modeling, drug discovery and patient-specific cell therapy. A major challenge in stem cell-mediated therapy is to understand and promote integration of transplanted stem cells into the host tissue. Fundamental to success of such therapies is development of robust methods to engraft stem cells and monitor their integration into the host network. Central to this theme, David Forsberg, Eric Herlenius and co-workers at Karolinska Institute (Stockholm) and Mahidol University (Bangkok) have recently published a comprehensive set of cutting-edge protocols in Unit 2D.13 of Current Protocols in Stem Cell Biology. The unit outlines methods to culture slices of striatal and brainstem tissue (organotypic culture) for  engraftment and integration of…
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