Platelet Rich Fibrin Therapy (PRF) is a second-generation PRP where blood platelets and leucocytes are present in a complex fibrin matrix to help accelerate the healing of soft and hard tissue. Platelet rich fibrin contains, and releases through degranulation, several different growth factors and other cytokines that stimulate the healing of bone and soft tissue.
The efficacy of certain growth factors in healing various injuries and the concentrations of these growth factors found within platelet rich plasma therapy are the theoretical basis for the use of PRP in tissue repair. The platelets collected in PRP are activated by the addition of thrombin and calcium chloride, which induces the release of the mentioned factors from alpha granules. The growth factors and other cytokines present in PRP include: platelet-derived growth factor, transforming growth factor beta, fibroblast growth factor, insulin-like growth factor 1 and 2, vascular endothelial growth factor, epidural growth factor, Interleukin 8, keratinocyte growth factor, and connective tissue growth factor.
Platelet Rich Fibrin is produced from a person’s own blood. It is a concentration of one type of cell, known as platelets, which circulate through the blood and are critical for blood clotting. Platelets and the liquid plasma of the blood contain essential factors for the cell recruitment, multiplication and specialization required for healing.