Neuroscientists Focus on Cell Mechanism That Promotes Chronic Pain

Researchers have discovered a new pain-signaling pathway in nerve cells that eventually could make a good target for new drugs to fight chronic pain. The findings, published in the journal PLoS Biology by a UT Dallas neuroscientist and his colleagues, suggest that inhibiting a process called phosphorylation occurring outside of nerve cells might disrupt pain signals, and…

Preventing Shingles in RA Patients

The live varicella-zoster vaccine can effectively prevent shingles in rheumatoid arthritis patients starting treatment with the drug tofacitinib, according to results of 2 recently-published studies in Arthritis & Rheumatology. Patients who received the shingles vaccine several weeks prior to the start of treatment for arthritis with tofacitinib demonstrated robust immune responses that were sustained even after the…

Easing Pain: complementary therapies

Psychologists are exploring complementary therapies and integrated approaches to better treat the complex problem of chronic pain. If cancer is “the emperor of all maladies,” as physician and author Siddhartha Mukherjee wrote, chronic pain may be the empress, affecting 100 million people in the United States and costing up to $630 billion each year in…

Peripheral Nerve Stimulation Reduces Chronic Headaches

Peripheral nerve stimulation (PNS) is an effective long-term treatment for managing chronic intractable headaches, suggests research published in Pain Physician. In this retrospective study, peripheral nerve stimulation reduced mean headache severity on the 11-point Numeric Rating Schedule (NRS) by nearly 50% within one-month post implantation. After 12 months, headache severity scores decreased by at least 50%…

Autonomic neuropathy in diabetic neuropathy

Autonomic neuropathy in diabetic neuropathy has an effect on hypoglycemia symptoms. Autonomic neuropathy is when the nerves that control bodily functions become damaged. Blood pressure, temperature control, digestion, bladder function and sexual function can all be affected by autonomic neuropathy. Normally, nerves send messages to the brain and other organs to ensure they function properly.…

Brain discovery leads to new treatments for neuropathy

Peripheral neuropathy is a debilitating condition for which there are few effective treatments, mainly because we do not fully understand the underlying molecular mechanisms, say researchers whose latest discovery appears to shed new light in this area. The team, from McGill University in Montreal, Canada, reports the discovery in The Journal of Neuroscience. They hope…