Cell adaptation helps repair damage

Genetic processes that allow cells to transform so they can mend damaged nerves have been identified by scientists. Their insights on tissue repair could advance the search for drug therapies to improve regeneration after injury, experts say. Researchers focused on injury to cells in the peripheral nervous system (PNS) – the crucial network of nerves…

Multivitamins May Reduce CIPN

Women who take multivitamin supplements before their breast cancer diagnosis and during chemotherapy appear to be less likely to develop the debilitating, often long-lasting symptoms of chemotherapy-induced peripheral neuropathy (CIPN), according to a new study.   In a large study of breast cancer patients undergoing paclitaxel chemotherapy, those who used multivitamins were about 40% less…

Neuroscientists Focus on Cell Mechanism That Promotes Chronic Pain

Researchers have discovered a new pain-signaling pathway in nerve cells that eventually could make a good target for new drugs to fight chronic pain. The findings, published in the journal PLoS Biology by a UT Dallas neuroscientist and his colleagues, suggest that inhibiting a process called phosphorylation occurring outside of nerve cells might disrupt pain signals, and…

Preventing Shingles in RA Patients

The live varicella-zoster vaccine can effectively prevent shingles in rheumatoid arthritis patients starting treatment with the drug tofacitinib, according to results of 2 recently-published studies in Arthritis & Rheumatology. Patients who received the shingles vaccine several weeks prior to the start of treatment for arthritis with tofacitinib demonstrated robust immune responses that were sustained even after the…

Integrating Stem Cells into Functional Neural Networks

The inherent potential of stem cells to engender any cellular form and function drives the field of regenerative medicine. In recent years, stem cell research has witnessed prolific growth particularly in disease-modeling, drug discovery and patient-specific cell therapy. A major challenge in stem cell-mediated therapy is to understand and promote integration of transplanted stem cells…

Pain Points

Neurobiologist Clifford Woolf discusses the importance of pain points and the surprising twists of his latest research Pain—feared, misunderstood and even poeticized in works of art and literature—has long captivated the scientific imagination of Clifford Woolf since his days as a medical student in South Africa. Woolf, a Harvard Medical School professor of neurobiology and neurology at…